A New Hope: The Nervous System

Brave early adopters are the hallmark of an innovation set to create immense human value. In this story, the innovation is cutting-edge technology for interfacing with the nervous system, and the brave early adopter is Ian Burkhart.

Ian, a young man in his mid-twenties, suffered a C5 spinal cord injury (SCI) during a diving accident in 2010. The result was bilateral paralysis below his elbows. With an admirably positive attitude and a wonderfully helpful community, Ian was able to make modifications to his life and still live with a sense of meaning.

One of the primary factors motivating Ian forward through the years of rehabilitation was the strong hope that, at some point in his lifetime, there would be biomedical advances capable of giving him back use of his hands.

As it happened, such a possibility crossed his path.

Image: https://ianburkhart.com

In 2014, Ian was presented with an incredible but uphill opportunity led by Dr. Chad Bouton of Battelle (he’s now with the Feinstein Institute): a team of researchers was looking for a patient to test out a system for restoring movement to the hands of a paralyzed patient. The catch was that it required brain surgery and extensive training.

There are 5.4 million Americans living with some form of paralysis, and Ian is acutely aware of the challenges they face. But optimism is one of his defining characteristics: given the chance to pioneer a technology that could bring massive human value, he was willing to make a sacrifice. And so, in 2014, Ian risked his life by undergoing electable brain surgery, implanting a manmade electrode array into the left motor cortex of his brain.

Over the four years since the operation, and hundreds of hours of tedious and extremely difficult training, Ian has collaborated closely with a team of researchers to improve the brain-machine interface system. Ian can now use the technology, which acts as a “bypass” to his damaged spinal cord, to play Guitar Hero using his right hand.

Image: PBS

The body has two information pathways, the vascular system and the nervous system. The typical conception of physiological medical care is that treatments should leverage the body’s vascular system, as in the case of pharmaceuticals; Ian’s system, in contrast, is based on the principle that medical care can be given by interacting with the nervous system. The names of the fields that embody this innovative approach are bioelectronic medicine (BEM) and brain-machine interfaces (BMI).

Brain-machine interfaces are technological systems that read from and/or write to the brain. Bioelectronic medicine systems are technological systems that read from or write to the nerves in your body (the peripheral nervous system). Both of these types of neural interfaces can provide therapeutic value through the insight to target medical interventions at the nervous system rather than just the bloodstream.

At Loup Ventures, we invest in domains of frontier technology that offer strong investment opportunities built on delivering unique human value-add. Bioelectronic medicine and brain-machine interfaces check both boxes with bold strokes. We’re here to explain these technologies and why you should care about them.

Starting with a story

Ian Burkhart was originally approved by the FDA to participate in a year-long trial using a Utah Array electrode implanted in his left motor cortex. When fully hooked up in the laboratory, the signals recorded from the Utah Array, a type of intracortical multielectrode array, are decoded by a neural decoding algorithm and used to control 130 surface electrodes wrapped around his right forearm (which he can’t move on his own). When current is run through the surface electrodes, it causes muscles in Ian’s forearm to contract in particular ways, ultimately controlling his hand movement. In other words, the researchers aim to understand what Ian’s neural activity looks like when he’s thinking about moving his hand. With this understanding, they can use his neural activity to decipher when he wants to move his hand. Then, knowing that he wants to move his hand, a computer program controls his muscles via the electrodes so he can actually move his hand. In essence, they skip right over the spinal cord injury responsible for his paralysis.

Image: biomedicalcomputationreview.org

Ian and his team of researchers have been so successful that the FDA has extended the experiment multiple times; he’s now in his fourth year of participation.

Loup Ventures recently had the pleasure to talk with Ian about his experience and his outlook. Here’s some of what we learned (listen to one of our conversations with him on our Neurotech Podcast here):

  • Each day he uses the system, Ian has to retrain the algorithms that decode his neural activity. This is because the specific neural activation representing his thoughts changes frequently due to neural plasticity. When Ian first started with the BMI system, he would leave training sessions mentally exhausted. Over the years, however, it’s become much easier; training isn’t something he has to pay much attention to, now. This has implications for future BEM/BMI technologies: it will be critical to minimize training time and repetition and to make the necessary training as pleasant as possible for the user.
  • Ian has spent time learning about the neural decoding algorithms themselves to the extent that he understands the different parameters the research engineers can tune. Now, when Ian is trying to make the BMI perform as well as it can, he can suggest that the researchers adjust specific parameters. This is similar, in a sense, to adjusting the speed of your mouse cursor on your computer screen. In general, this insight from Ian suggests that BEM/BMI systems ought to be designed like any piece of software, where there’s a symbiosis between the user and the machine. The better the user can intuit how the machine will understand him/herself (and vice versa), the more effective the system will be. Ian is very insistent that in order for mass adoption, the technology must be user-friendly; just because its value proposition (i.e. returned movement) is so large doesn’t mean that normal human-centric design considerations can be thrown out the door.
  • Even though Ian is very excited about the progress he’s making with the research system in a laboratory setting, he can’t take the system out of the lab yet—partly due to regulation and partly due to the unwieldiness of the technology.
  • Even amongst spinal cord injury patients, Ian sees resistance to the adoption of brain-machine interfaces. This paper has great data about which types of interfaces paralysis patients would be comfortable with, given specific types of benefits they can receive. For example, as compared to typing, controlling a cursor, and moving a robotic arm, patients were overwhelmingly most interested in using neural interfaces to control the movement of their own limbs.
  • Ian emphasized to us over and over again that brain-machine interfaces and bioelectronic medicine systems must be designed to provide as much value to the user as possible; this bears repetition since most systems are currently in the hands of research scientists and research engineers, not user experience designers.
  • We’re discussing a technology that plugs directly into a human brain; this conversation would be woefully incomplete without discussing ethics. Ian pushed this point, since he clearly sees the potential for good in neurotechnology, but acknowledges there’s also potential for bad. One example we think is particularly relevant given current conversation about software platforms is user privacy. User privacy takes on a whole new meaning when the data isn’t just behavioral (like clicking on an ad), but neural. Through the talks he’s given and the other SCI patients he’s spoken with, Ian recognizes that there will be big pushback on technologies that interface with the nervous system, and we think the pushback can be healthy if addressed constructively. With current screen-based interfaces, there have clearly been both positives and negatives. In general, as technology becomes more directly able to “extract” information from, and “input” information into us, the privacy and digital wellbeing stakes get higher. Any foray into the therapeutic benefits of BMI/BEM—whether as an interested onlooker, an investor, a researcher, or a company—would be ill-advised without strong considerations for, and safeguards to protect, the ethical implications of the BMI/BEM product.

In general, we take inspiration from Ian’s conviction about the positive value of nervous system-based interventions, and we take direction from his emphasis on the necessity for BMI/BEM engineers to focus on the practical value of their products. In speaking about his work to improve his own system for movement restoration so that other patients can use it, he says, “I see my involvement with the study as a job that I have to succeed in.” He sees no other choice; the upside is just too large to ignore.

The general bioelectronic medicine approach

Now that we’ve discussed bioelectronic medicine and brain-machine interfaces from the perspective of a real user, we’ll describe these related domains and their benefits to conclude this introductory article. Although the fields of bioelectronic medicine and brain-machine interfaces speak to different use-cases (bioelectronic medicine involves the peripheral nervous system and treats or diagnoses disease in the body; brain-machine interfaces involve the central nervous system and address sensory deficits and cognitive/affective disorders), we’re going to discuss both under the header of “bioelectronic medicine” for the sake of brevity and comprehensibility.

At its highest level, bioelectronic medicine simply uses electronics to interface with the body where previously, chemicals/drugs would have been used. There are three basic components to any BEM system: a body, a device (either inside or outside of the human body), and a computer. In plain English, there are two general ways to use a BEM system:

  1. A device is used to record electrical or chemical signals from the body, and a computer interprets those signals in order to understand the state of the body or a specific system within it.
  2. A device is used to stimulate electrical (or other) signals within the body in order to have a desired therapeutic or enhancing outcome, and a computer controls the stimulation.

Some examples of BEM systems include: brain-machine interfaces for restoring movement to paralyzed patients, as in the case of Ian Burkhart; retinal prostheses to return vision to the blind; stimulating the vagus nerve to treat rheumatoid arthritis; and recording electrical signals from the vagus nerve to understand the state of the body’s inflammatory response.

Image: Tracey, 2007

The latter two use-cases exemplify an aspect of bioelectronic medicine that differs from central nervous system-focused brain-machine interfaces: bioelectronic medicine leverages reflexes. In this sense of the word “reflex,” we refer to the idea that the brain both keeps track of and controls organ function using peripheral nerves. This keeping track and controlling is a reflex to preserve homeostasis.

Regulatory and cost advantage

Aside from providing novel treatments and diagnostic opportunities that have yet to be achieved with pharmaceuticals, bioelectronic medicine products offer significant advantages over pharmaceuticals in terms of the FDA regulatory process. All medical devices and drugs are subject to regulation by the FDA. However, it takes between 30–50 months for a medical device (BEM devices classify as medical devices) to get through the FDA, as compared with 144 months for a drug to get through the FDA. A direct correlate of this is that BEM device development is significantly less expensive than pharmaceutical development: BEM devices cost ~$100M for high-risk devices, whereas drug development can require on the order of ~$1B (although the exact cost is uncertain and fluctuates).

Frontiers

There are several frontiers of bioelectronic medicine: technological, scientific, and social/political. Technologically, devices to record and stimulate the nervous system need to be able to record and stimulate at smaller spatial scales and to operate wirelessly (without a wire running from the implanted device, out of the skin, and to a power source). Additionally, neural recordings will be fused with sensors under development that focus on biological signals such as the activity within individual cells. In terms of basic science, researchers need a better understanding and more detailed atlas of the peripheral nervous system and are additionally working to characterize other nervous system reflexes within the body (“reflex” in the sense we described above). Finally, on the social/political front: although public forum discussion of BEM and BMIs is rather small right now, it’s likely that conversation picks up over the next ~5 years as ambitious interface companies like Neuralink, Kernel, and Paradromics hopefully bring progress to bear; almost certainly, the public conversation will focus on privacy and ethics.

Market size: understanding the prospects

To understand the massive market for therapeutic devices that interface with the nervous system, we’ll list six example opportunities and their respective market sizes:

  • Spinal Cord Injury – 280,000 patients in the US as of 2016, with a $2.3B global market as of 2017.
  • Alzheimer’s Disease – 5.7M patients in the US, with a $1.7B market in North America as of 2017.
  • Amyotrophic Lateral Sclerosis – 30K patients in the US, $16M market in the US as of 2018.
  • Stroke – 795,000 strokes per year in the US (144,000 deaths per year caused by strokes); $6.5B market in the US as of 2016.
  • Rheumatoid Arthritis – 1.5M patients in the US; $11.5B market in the US as of 2016.
  • Mental Health/Substance Abuse – 43.8M adults in the US experience mental illness annually; based on data through 2013, the US mental health and substance abuse services industry was expected to produce $53.2B in revenues in 2017.

Expanding beyond these specific use-cases, any new class of treatment and diagnostic methodology like bioelectronic medicine is likely to have effects that trickle down and impact a large portion of the $3.3 trillion dollar US healthcare industry.

In Conclusion

In this piece, we’ve introduced the concept of bioelectronic medicine and brain-machine interfaces: providing therapeutic value to patients by interfacing with their nervous system instead of their bloodstream. We see huge opportunity in this space, driven by novel interfaces to the nervous system and new disease treatment paradigms. As we saw with Ian Burkhart, bioelectronic medicine and brain-machine interfaces are domains with enormous value to add, but whose development will be intricate and require careful ethical considerations. Stay tuned as we dive in-depth to understand the science, technology, and business of bioelectronic medicine.

Special thanks to Ian Burkhart for sharing with us his story and insights. Through the Ian Burkhart Foundation, he works to improve the lives of individuals with spinal cord injuries.

Disclaimer: We actively write about the themes in which we invest: virtual reality, augmented reality, artificial intelligence, and robotics. From time to time, we will write about companies that are in our portfolio. Content on this site including opinions on specific themes in technology, market estimates, and estimates and commentary regarding publicly traded or private companies is not intended for use in making investment decisions. We hold no obligation to update any of our projections. We express no warranties about any estimates or opinions we make.

Investing in Paradromics

Neurotechnology has long been a passion for Loup Ventures because we think it represents a vast and open opportunity to improve human life via both restoration and augmentation. Brain-computer interfaces are one of the most compelling areas in the neurotech space and we’re excited to invest in Paradromics as they work to capitalize on that opportunity.

To date, many of the BCI solutions have been relatively low bandwidth, leveraging surface electrodes or other non-invasive methods to collect signals from the brain. Paradromics, along with Neuralink (Elon Musk), is one of only a few companies that are attacking an emerging theme around high-bandwidth, invasive brain-computer interfaces.

We’re investing in Paradromics as a play on two of our thematic focus areas: AI and experience.

AI. Paradromics is a hardware and software company. The company creates a device that consists of an implantable microwire array that allows for the high-density collection of neuronal data. The brain has ~100 billion neurons. The current standard in implantable BCI devices, the Utah Array, has about 100 channels (connection points to the brain) and each channel connects with a handful of neurons. Paradromics’ solution currently has over 65,000 channels, and the company’s goal is to connect with over a million neurons.

The collection of such a large array of data presents a unique challenge in that tens of thousands of connection points with the brain yields massive amounts of data to process (tens of GB/sec). To put that in perspective, average high-speed Internet connections are around 20 MB/sec or more than 1,000 times slower. To address this, Paradromics has developed a proprietary tool that allows them to more efficiently process certain elements of the signal to allow for high-resolution analysis of a neuronal signal while compressing the data transferred to more manageable levels.

Experience. In our Manifesto, we outlined the future of computer interfaces moving from phones, to wearables, to implants. Paradromics is also a bet on the last of the three stages. To the extent that we can read (and eventually write to) the brain, we can achieve our long-term vision of a world where it’s possible to create life-like experiences directly via brain-computer interface. This augmentative future is far away, and initial use cases will center on therapeutic outcomes, but we believe the groundwork will be established now to achieve this goal.

Paradromics is attacking the true frontier of frontier technology. Their service has the potential to change human lives near-term for those afflicted with disorders of the brain, as well as long-term as an augmentative tool. We believe the therapeutic market is likely several billion dollars in opportunity, while the augmentative opportunity may be significantly larger.

Disclaimer: We actively write about the themes in which we invest: virtual reality, augmented reality, artificial intelligence, and robotics. From time to time, we will write about companies that are in our portfolio.  Content on this site including opinions on specific themes in technology, market estimates, and estimates and commentary regarding publicly traded or private companies is not intended for use in making investment decisions. We hold no obligation to update any of our projections. We express no warranties about any estimates or opinions we make. 

008 – Ian Burkhart

Ian Burkhart was born in 1991 in Columbus, Ohio. He is the oldest of four children and was actively involved in lacrosse and boy scouts throughout his youth. During the summer after his freshman year, Ian and a group of friends were on vacation in North Carolina when he suffered a traumatic spinal cord injury after diving headfirst into a sandbar. After being diagnosed as a C5 quadriplegic, Ian discovered a way to participate in a neural bridging study with The Ohio State University Wexner Medical Center and the Battelle Memorial Institute. Ian has stayed active in his community and on campus at Ohio State University, where he is currently pursuing a degree in Accounting. As an assistant coach for the varsity lacrosse team at Dublin Junior High School, he has helped lead the team to a state championship and three runner-up finishes since joining in 2011. Ian is also a Peer Support Mentor with the Christopher and Dana Reeve Foundation volunteering with the Ohio State University Wexner Medical Center where he helps patients with spinal cord injuries adjust to their new life.

Top 3 Takeaways.

  1. Despite all that has changed in his life, Ian’s core wish is that neural interfaces could advance faster for the benefit of others living with similar conditions.
  2. While the technical development and engineering behind neurotechnology applications are important, Ian feels that doctors and companies alike can provide the most value by spending quality, face-to-face time with patients to learn about how they can improve patient life and teach the patients about the devices.
  3. Ian’s belief in himself and the future of neurotechnology have taught him the power of a positive, forward-thinking mindset, which is something we all can learn from.

Show Notes.

  • [1:05] Ian shares the story of his life-changing accident at 19 years old.
  • [2:39] Ian’s introduction to neural implants as a C5 quadriplegic and a technological optimist.
  • [4:00] How the study to regain control of his hands was initially presented to Ian and his drive for an increase in independence and quality of life.
  • [6:03] An overview of Ian’s training process and how he trained a computer to learn how he thinks.
  • [7:38] Ian shares how he was able to overcome the difficulty of small, simple movements.
  • [10:48] A walkthrough of the progress Ian has made and what his new goals are.
  • [12:10] When will the training technology be available outside of a laboratory setting?
  • [14:05] Ian shares his view on what a patient feels is most important for providers in this space to know.
  • [15:40] The progress Ian has been able to make outside of the lab without using the training system.
  • [17:30] Ian shares what he believes to be the key to his success: positive thinking.
  • [19:16] In Fall 2017, Ian launched the Ian Burkhart Foundation to help provide financial assistance to individuals with spinal cord injuries.

Selected Links.

Related Podcasts.

Disclaimer: We actively write about the themes in which we invest: artificial intelligence, robotics, virtual reality, and augmented reality. From time to time, we will write about companies that are in our portfolio. Content on this site including opinions on specific themes in technology, market estimates, and estimates and commentary regarding publicly traded or private companies is not intended for use in making investment decisions. We hold no obligation to update any of our projections. We express no warranties about any estimates or opinions we make.

007 – Chad Bouton

Chad Bouton is the Center Head and Director of Bioelectronic Medicine (BEM) at the Feinstein Institute, the world’s leading research institute for this field. As an undergraduate student at Iowa State University (ISU), Bouton focused on electrical engineering. While in graduate school at ISU, he slowly gravitated towards physics and robotics, eventually leading to his first role in healthcare studying signal processing in the brain at Battelle. At Battelle, Bouton played a key role in developing neural coding methods that helped restored function in a paralyzed patient for the first time with a neural implant. He was recognized as “Inventor of the Year” and “Distinguished Inventor” by Battelle.

Top 3 Takeaways.

  1. The success of bioelectronic medicine will depend on how BEM will impact quality of life by identifying the needs of patients first.
  2. There are over 25 million people living in the world living with some form of significant paralysis.
  3. BEM has tremendous potential to impact both quality of life for individuals living with life-changing diseases as well as helping advance early detection methods for these diseases.

Show Notes.

  • [00:50] Chad’s original start in engineering which later led him to robotics and mechanics in grad school eventually leading to studying the brain signals of patients with paralysis.
  • [2:10] How to think about the differences between Brain Machine Interfaces and Bioelectronic Medicine.
  • [4:49] The potential of BEM to replace traditional pharmaceuticals being and the history of inflammatory reflexes.
  • [7:10] How far along are we from cracking “the neural code”?
  • [8:59] Theo Zanos’s research on “information extraction” from the Vagus Nerve that could help provide an indication of status or function of various organs in the human body.
  • [10:15] Why is BEM receiving a lower level of press compared to BCI?
  • [12:40] Why everything in BEM can be considered a feedback loop.
  • [14:07] Results from Chad’s research with BCI in restoring control for individuals dealing with paralysis.
  • [15:50] How training modalities for patients using devices will evolve in the coming years and why a focus on identifying mistakes instead of successes may help speed up the process.
  • [18:30] Where do the greatest difficulties lie with extracting data from the brain and then processing the data?
  • [21:10] Chad shares his thoughts on the potential for convergence of BCI and BEM.
  • [24:15] Targeting medical conditions is the greatest near-term need for BEM. It’s not a question of “if” but “when” we will have implants focused on enhancing quality of life.

Selected Links.

Related Podcasts.

Disclaimer: We actively write about the themes in which we invest: artificial intelligence, robotics, virtual reality, and augmented reality. From time to time, we will write about companies that are in our portfolio. Content on this site including opinions on specific themes in technology, market estimates, and estimates and commentary regarding publicly traded or private companies is not intended for use in making investment decisions. We hold no obligation to update any of our projections. We express no warranties about any estimates or opinions we make.

006 – Dr. Stephen Rainey

Dr. Stephen Rainey. Dr. Rainey is a research fellow at the Oxford Uehiro Centre for Practical Ethics. He is a working in the Horizon2020-funded project BrainCom, developing therapeutic brain-computer interfaces that will enable communication for users with debilitating speech conditions. Dr. Rainey studied philosophy in Queen’s University Belfast and obtained his PhD in 2008 with a thesis on rationality. He has taught a range of philosophical topics and worked on a number of European Commission-funded research projects. These have included work on ethics, emerging technologies, and governance.

Top 3 Takeaways.

  • Covert speech plays a key role in the development of neuroprosthetics while also presenting a problem on how to accurately filter thoughts meant to be kept internally versus expressed verbally.
  • Dr. Rainey’s background in philosophy helped shape his belief that the future of neural discoveries is dependent on the collaboration of experts with interdisciplinary backgrounds because every discipline has different constraints.
  • Humans tend to form visions of the future that aren’t much different than the present, which leads to dystopian views rather than utopian. The reality is something in between, hopefully closer to the latter, that wasn’t considered in the first place.

Show Notes.

  • [0:45] Stephen’s background in philosophy that eventually led him to a career in neuroscience, ethics, and emerging technologies.
  • [3:19] How are neuroprosthetics able to determine what is shielded vs. shared from the real world?
  • [4:44] How thought-to-text processes are different than thought-to-speech processes.
  • [7:33] Accuracy vs. Authenticity as it relates to neuroprosthetic devices.
  • [10:12] The interface amongst neuroscientists who come from varying interdisciplinary backgrounds.
  • [14:50] Scaling the concept of ethics for emerging technologies and the future of regulation.
  • [20:24] What is the “meaning of life” in an autonomous future?
  • [24:03] Stephen’s favorite books related to ethics and BCI.

Selected Links.

Related Podcasts.

Disclaimer: We actively write about the themes in which we invest: artificial intelligence, robotics, virtual reality, and augmented reality. From time to time, we will write about companies that are in our portfolio. Content on this site including opinions on specific themes in technology, market estimates, and estimates and commentary regarding publicly traded or private companies is not intended for use in making investment decisions. We hold no obligation to update any of our projections. We express no warranties about any estimates or opinions we make.